Taking Psilocybin at a Macro-dosage, usually defined as between 2 and 5 grams of dried psilocybin mushrooms, has been shown by several scientifically meticulous studies to reliably elicit spiritual, mystical, or transcendent experiences that have lasting positive effect on the subject, with as little as one (large) dose.
In the modern day psilocybin is often used with one of two intents; recreational use or therapeutic use. When administered in a therapeutic setting it has proven to be highly effective in lowering anxiety, treating depression, breaking addiction, and alleviating the symptoms of PTSD.
Studies at Harvard, Stanford, Yale, University of Toronto, Johns Hopkins University, and many other educational/research institutions have proven psilocybin’s efficacy in treating the aforementioned psychological conditions. These studies also corroborated beliefs that indigenous peoples have held into antiquity – that in addition to its medical applications, psilocybin also has the potential to radically improve the well-being, happiness, and overall mental state of ‘healthy’ individuals.
Based on the results of these studies, the U.S. Federal Drug Administration has also recently given psilocybin a “Breakthrough Therapy” designation, which is granted only when preliminary evidence suggests the drug may be an enormous improvement over already available therapy. This designation will fast-track many potential psilocybin treatments through clinical trials, which are underway. Health Canada has also awarded multiple licenses for the research and development of a psilocybin treatment.
Magic mushrooms are consistently rated by the Global Drug Survey (a yearly survey of over 100,000) to be one of the safest, and also one of the best value-for-money mind-altering substances.
That said, the potential for a negative experience does exist and is amplified the larger your dose. We recommend starting with 1.25 grams of dried mushroom for every 100 pounds of body weight (1g/100lbs for Penis Envy varieties).
There are also several other factors which play a significant role in a mushroom experience, like mindset, environment, auditory stimulation, and even your expectations! Its best to be as comfortable as possible. This means having knowledge of psilocybin’s potential effects, being in a familiar environment, and not having any obligations for 6-8 hours.